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     The main research focus in our department is to develop novel dental materials and biomaterials, regenerative therapies, and tissue engineering technologies which will be of benefit to achievement of innovative treatment methods of oral and craniofacial diseases. We are also conducting application of computer technology to biomechanical analysis of implants, teeth, and restoratives. Detailed research topics are as follows.
 
1. Development of next generation bio-active materials for restoration and prevention
   1) Development of restorative/preventive materials with antibacterial effects
   2) Development of restorative materials with tissue regeneration-promoting ability
2. Development of novel tissue engineering and regenerative technologies
   1) Development of bone regenerative therapy using scaffold-free 3D cell constructs
   2) Development of pulp regenerative therapy by transplantation of cell constructs
   3) Development of synthetic bioabsorbable membranes
3. Development of new materials for various dental treatments
   1) Optimization of resin composites structure in multi-scale
   2) Development of CAD/CAM resin composites for primary teeth
   3) Development of new thermoplastic materials for orthodontic treatment
4. In vitro/in silico evaluation of dental materials
   1) Evaluation of longevity of CAD/CAM resin composites
   2) Mechanical analysis of dental implants
5. In vitro evaluation of biofilm formation on restorative materials using an original bioreactor
 
     For many projects above mentioned, world-wide collaboration with university, research institutes, and dental materials manufacturers are in progress.
 


 1. Development of next generation bio-active materials for restoration and prevention

   1)    Development of restorative/preventive materials with antibacterial effects
      
      Antibacterial dental resin monomer MDPB (Left) and the world’s first commercial dental adhesive with antibacterial activity (Right)
 
      
      Antibacterial composites (Left) and antibacterial endodontic primer for root canal filling and cavity disinfectant incorporating MDPB (Right)
 
      
      Sustained antimicrobial-release systems using non-biodegradable polymer particles
 
   2)    Development of restorative materials with tissue regeneration-promoting ability
      
      Non-biodegradable polymer particle as carriers of growth factors

2. Development of novel tissue engineering and regenerative technologies 
   1) Development of bone regenerative therapy using scaffold-free 3D cell constructs 
      
      Scaffold-free 3D stem cell constructs (Left) and functionalization by osteogenic induction (Right)
 
   2) Development of pulp regenerative therapy by transplantation of cell constructs
      
      Fabrication of artificial pulp-like tissue composed of dental pulp stem cells for dental pulp regeneration

   3) Development of synthetic bioabsorbable membranes
      
      Bilayer bioabsorbable membrane, comprising solid and porous layers, for GTR/GBR therapy
 
3. Development of new materials for various dental treatments
   1) Optimization of resin composites structure in multi-scale
      
      Multi-scale analysis of CAD/CAM resin composites crown containing nano-sized fillers

   2) Development of CAD/CAM resin composites for primary teeth
      
      Evaluation of physical properties and wear resistance
 
 3) Development of new thermoplastic materials for orthodontic treatment
      
      Evaluation of physical properties of commercial orthodontic thermoplastic materials and development of new materials to exhibit optimal orthodontic force

4. In vitro/in silico evaluation of dental materials
   1) Evaluation of longevity of CAD/CAM resin composites
      
      Fatigue behavior and water resistance analysis

   2) Mechanical analysis of dental implants
      
      Evaluation of fracture property by fatigue tests and finite element analysis

5. In vitro evaluation of biofilm formation on restorative materials using an original bioreactor